AstraZeneca has been submitting its required drug-reporting documents electronically to the U.S. Food and Drug Administration since mid-2006 using the SAFE-BioPharmaTM digital signature standard. Summary (pdf)
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"Pfizer's Implementation of SAFE-BioPharma® Digital Signatures for Electronic Lab Notebooks,” is a 19-page white paper describing how the company successfully introduced to its Global Research and Development organization electronic notebooks signed with SAFE-BioPharma digital signatures. Pfizer’s digitally signed Chemistry electronic Notebooks (CeN) have more than 2200 users within Pfizer and average more than 1000 signatures per day. Summary (pdf) Full Story (pdf)